Recombinant Human ADSL/Adenylosuccinate Lyase Protein (His Tag)
SKU #
PKSH031168
Expression Host
E.coli
Description
Synonyms
AMPS,ASASE,ASL
Species
Human
Expression Host
E.coli
Sequence
Met 1-Leu 484
Accession
P30566-1
Calculated Molecular Weight
57.0 kDa
Observed Molecular Weight
53 kDa
Tag
N-His
Bio-activity
Not validated for activity
Properties
Purity
> 95 % as determined by reducing SDS-PAGE.
Endotoxin
Please contact us for more information.
Storage
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80. Reconstituted protein solution can be stored at 4-8 for 2-7 days. Aliquots of reconstituted samples are stable at < -20 for 3 months.
Shipping
This product is provided as lyophilized powder which is shipped with ice packs.
Formulation
Lyophilized from sterile PBS, 10% glycerol, pH 7.5 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution
Please refer to the printed manual for detailed information.
Background Adenylosuccinate lyase, also known as adenylosuccinase, ADSL or ASL, is an enzyme implicated in the reaction of adenylosuccinat converting to AMP and fumarate as part of the purine nucleotide cycle. The two substates of adenylosuccinate lyase (ADSL) are dephosphorylated derivatives of SAICA ribotide (SAICAR) and adenylosuccinate (S-AMP), which catalyzes an important reaction in the de novo pathway of purine biosynthesis. ADSL catalyzes two distinct reactions in the synthesis of purine nucleotides, both of which involve the _-elimination of fumarate to produce either aminoimidazole carboxamide ribotide from SAICAR or AMP from S-AMP. The Adenylosuccinate lyase deficiency is a rare autosomal recessive metabolic disorder characterized by the present of SAICA riboside and succinyladenosine (S-Ado). ADSL defect in different patients is often caused by different mutations to the enzyme.
Express delivery and return policies
Free shipping on orders over $30
Processing time: 1-2 Days
Shipping time: 3-5 Days(According to the logistics method and delivery address)
Items can be returned or exchanged within 30 days !
